Immunological parameters in gastric cancer patients treated with immunotherapy of streptococcal preparation OK-432.
نویسندگان
چکیده
منابع مشابه
Studies on the host-mediated action of the streptococcal preparation, OK-432, in cancer chemotherapy.
The streptococcal preparation, OK.432, with predominant host-mediated mode of action, was studied. By giving OK-432 to mice intraperitoneally prior to transplantation of Ehrlich carcinoma, a host-mediated action to increase life-span was clearly confirmed. Pretreatment with OK-432 was also effective against the development of Rauscher leukemia. The host-mediated action of OK432 varied with the ...
متن کاملIntratumoral administration of streptococcal preparation (OK-432) to advanced pancreatic cancer.
Ten patients with advanced, unresectable carcinoma of the pancreas were treated with intratumoral high-dose injections of OK-432 and their therapeutic responses assessed from the clinical standpoint in the past four years since 1977. Following the treatment, 7 (78%) of 9 patients evaluated by the Karnofsky criteria fell under Category I, of whom 2 were classified under I-C. Five patients (50 %)...
متن کاملBiochemical modulation of 5-fluorouracil with a streptococcal preparation, OK-432, against murine colon-26 carcinoma.
Conventional therapy for colorectal carcinoma using 5-fluorouracil (5-FU) has shown limited antitumor action. The purpose of our study was to investigate synergistic antitumor effects of the streptococcal preparation of OK-432 and 5-FU, and to elucidate the mechanisms of interaction between the 2 agents in mice. Biochemical modulation of OK-432 and 5-FU were determined in vivo against colon-26 ...
متن کاملAdoptive immunotherapy for malignant brain tumors using human peripheral blood mononuclear cells activated by the Streptococcal preparation OK-432.
Adoptive immunotherapy using OK-432-activated mononuclear cells (OK-MCs) offers cell-mediated and cytokine-mediated pathways for antitumor activity. The effectiveness of direct intratumoral administration of OK-MCs via a catheter/reservoir system was studied in patients with malignant brain tumors. Seventeen patients, 12 with malignant glioma, four with metastatic adenocarcinoma, and one with p...
متن کاملStreptococcal preparation (OK-432) inhibits development of type I diabetes in NOD mice.
OK-432 (a streptococcal preparation) has been widely used for cancer immunotherapy in Japan. It is the most potent immunomodulator in activating both macrophages and killer T cells and in increasing interleukin 2 production. Two K.E. (Klinische Einheit, clinical unit) of OK-432 were given intraperitoneally to each of 17 female nonobese diabetic (NOD) mice every week from 4-24 wk of age. NOD mic...
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 1982
ISSN: 1880-1293,0022-9717
DOI: 10.2302/kjm.31.159